Revascularization of Hibernating Myocardium

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Hibernating myocardium.

Decreased myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of hibernation implies a downregulation of contractile function as an adaptation to a reduction in myocardial blood flow that serves to maintain myocardial integrity and viability during persistent ischemia. Unequivocal evidence for this concept exists in scenarios of myocardial ischemia that last...

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Revascularization of hibernating myocardium: rate of metabolic and functional recovery and occurrence of oxidative stress.

BACKGROUND Left ventricular (LV) dysfunction due to coronary artery disease (CAD) may improve after revascularization in patients with hibernating myocardium (HM). METHODS AND RESULTS We compared the rate of metabolic (arterial-great cardiac vein differences of lactate, glucose and pyruvate) and functional (intra-operative transesophageal and epicardial echocardiography) recovery and occurren...

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Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularization.

BACKGROUND The identification of hibernating myocardium is important in selecting patients who will benefit from coronary revascularization. This study was performed to determine whether dobutamine stress echocardiography (DSE) could identify hibernating myocardium and predict improvement in regional systolic wall thickening after revascularization. METHODS AND RESULTS DSE was performed in 49...

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Identification of Therapeutic Benefit from Revascularization in Patients with Left Ventricular Systolic Dysfunction: Inducible Ischemia versus Hibernating Myocardium Ling et al: Therapeutic Implications of Hibernating and Ischemic Myocardium

l A Ins ns ns ns nsti ti ti ti titu tu tu tu ute te te te te a a a a and n n n n 2 Imaging Institut t t t te, Abstract Background—Although the recent STICH substudy reported that revascularization of viable

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Classical teaching about myocardial ischemia is now being challenged by exciting new concepts that have been evolving over the past two decades. It is now recognized that prolonged myocardial ischemia does not inevitably lead to irreversible necrosis of myocardial tissue. Similarly, segment dysfunction in the ventricle does not necessarily imply that the myocardium in that area has undergone in...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2015

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2014.12.024